A KFF analysis of the latest data from the U.S. Centers for Disease Control and Prevention finds that the national alcohol death rate has risen 70% in the past decade, accounting for 51,191 deaths in 2022 — up from 27,762 deaths in 2012. The analysis has state-level data showing considerable variation in alcohol death rates across states. Deaths rose sharply during the pandemic, with the steepest increases among adults aged 26 to 44, American Indian and Alaska Native people, and females—all groups that experienced close to, or more than, a 100% rise in alcohol mortality rates since 2012.